The song was written by Ernie Maresca and It was recorded in 1961 by Dion, backed by vocal group The Del-Satins. Released on Laurie Records, it topped the Billboard Hot 100 for one week in October of that year, and also reached number 11 in the UK charts.

It is a song about a man whose ex-girlfriend had commitment trouble and „ran around” (hence the name of the song) „with every single guy in town”. The song caught on with millions for its catchy backing hook „Hey, hey, hum-ba-diddy-diddy”. Dion states that it was inspired by Sue Murphy of Arlington, TX.

In the liner notes of Dion’s box set King Of The New York Streets, he writes:
It came about by partying in a schoolyard. We were jamming, hitting tops of boxes. I gave everyone parts like the horn parts we’d hear in the Apollo Theater and it became a jam that we kept up for 45 minutes. I came up with all kinds of stuff. But when I actually wrote the song and brought it into the studio to record it, well, her name wasn’t actually Sue. It was about, you know, some girl who loved to be worshipped but as soon as you want a commitment and express your love for her, she’s gone. So the song was a reaction to that kind of woman.

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